Dr. Sushmitha J, Dr Vimal M, Dr Karthikeyan K, Dr Sriram V.


II year Post graduate(Pathology), Professor(Department of Pathology), Professor and Head(Department of Dermatology), Associate Professor(Department of Pathology)


Psoriasis is a chronic, relapsing, papulosquamous dermatitis, characterized by abnormal hyperproliferation of the epidermis. As immunological mechanisms play a major role in the pathogenesis of psoriasis, there has been a need for biomarkers which should be simpler and easily measurable.

Aims and Objective:

To study the histomorphological and hematological parameters in Psoriasis and to correlate it with Clinical features.

Materials and Methods:

This is a cross sectionalstudy in which 50 cases of Psoriasiswere studied for a period of 18 months.


Of the 50 psoriasis cases that were studied, Male preponderance(70%) was noted with predominant cases having lesions in extremities(35%) and trunk(32%). The most common clinical feature was found to be plaque(98%), followed by itching(78%) and scaling(68%). The common histopathological features seen are acanthosis(84%) and parakeratosis(96%) and lymphocytic infiltration was seen in all the cases.The histopathological feature ofsupra-papillary thinning correlated with Auspitz sign(p=0.002).48% of the cases showed normocytic normochromic anaemia with increased neutrophil counts. The mean Neutrophil-Lymphocyte ratio(NLR) was2.15±1.68 and Platelet-Lymphocyte Ratio(PLR)was 132.3 ± 41.1.


Due to varied clinical presentation in Psoriasis, histopathological examination and hematological parameters plays a crucial role in diagnosis and helps in assessing disease severity.The information thus obtained can haveimplications in better patient management.