Central Research Laboratory – Sri Manakula Vinayagar Medical College and Hospital

Central Research Laboratory (Department of Biochemistry)

Administrative control	Dr. P Sanjay, MDS,DNB, MOMSRCPS (Glasgow) Dean Research Professor & Head, Department of Dentistry, SMVMCH Dr. Kulkarni Sweta, MD Biochemistry Professor & Head, Department of Biochemistry, SMVMCH.
Faculty	Dr. Tresa Remya A T, Ph.D, Research Scientist, Central Research Laboratory, Department of Biochemistry, SMVMCH.
Faculty	Ms. B. Shalini M.Sc., Research Assistant, Central Research Laboratory, Department of Biochemistry, SMVMCH.
Staff	Mrs. J. Anusuya Lab Technician Central Research Laboratory Department of Biochemistry, SMVMCH

Equipments

S.No	Name of the Instrument
1	High –Performance Liquid Chromatography (HPLC)
2	Gel Documentation System
3	ELISA reader
4	ELISA washer
5	Thermal cycler (labnet)
6	Gradient thermal cycler (Bio-Rad T100)
7	Cooling Centrifuge
8	Research Centrifuge
9	Electrophoresis apparatus
10	Spectrophotometer
11	BOD Incubator
12	Incubator
13	-20°C Deep Freezer
14	Magnetic Stirrer with Hot plate
15	pH Meter
16	Refrigerator (Samsung)
17	Refrigerator (Whirlpool)
18	Bench top centrifuge
19	Centrifuge
20	Centrifuge
21	Microwave Oven
22	Water bath
23	Mini centrifuge (Eppendorf)
24	Microfuge (PCR tubes)
25	Vortexer

List of ongoing projects: (14 Projects)

S. No	Project Title	Principal Investigators	Co- Principal Investigators
1.	Correlation between serum apelin levels with left ventricular mass in type 2 diabetes mellitus patients	Dr. Deepsheeka. G. (PG) Dept. of General Medicine	Prof. Dr. A. K. Badrinath Dept. of General Medicine
2.	Covid 19 vaccination in pregnancy-The covid study	Dr. G. Kalaiselvan Professor & Head, Dept. of Community Medicine	Mr. Balachander Dept. of Community Medicine
3.	Autoimmune diabetesin patients with type 2 diabetes mellitus- a hospital based study	Dr. Pooja N. U. (PG) Dept. of General Medicine	Dr. S. Girija Dept. of General Medicine
4.	Study of comparison of high sensitive CRP to pre albumin ratio in acute coronary syndrome patients	Dr. Aakash T. Ajith (PG) Dept. of General Medicine	Prof. Dr. A.K. Badrinath Dept. of General Medicine
5.	Serum Folic acid assay on long term Methotrexate therapy in Psoriatic patients	Dr. Jayapratha. S (PG) Dept. of Dermatology	Dr. K.Karthikeyan Dept. of Dermatology
6.	A study of comparison of serum Keratin-18 level with child pugh ‘s score in assessing severity in patients with end stage alcoholic liver disease	Dr. B. Vidhya (PG) Dept. of General Medicine	Dr.M.K. Uthaya Sankar Dept. of General Medicine
7.	Comparing urine Trypsinogen activating peptide with C-reactive protein, serum amylase in assessing the severity of acute alcoholic pancreatitis	Dr. T. Shobana (PG) Dept. of General Medicine	Dr.C. Manokaran Dept. of General Medicine
8.	Correlation between IL-6 and the angiographic severity of Coronary artery disease in Acute coronary syndrome patient	Dr. Ezhil Kumar. M (PG) Dept. of General Medicine	Dr.M.K. Uthaya Sankar Dept. of General Medicine Dr. Ashida T.S. Department of Cardiology
9.	Identification of clusters of Type 2 Diabetes mellitus and its association with micro vascular complications- A rural hospital study	Dr. A. Naveen (PG) Dept. of General Medicine	Dr. S. Girija Dept. of General Medicine
10.	A study on the clinical significance of serum Interleukin-6 in heart failure patients	Dr. Harikrishnan G.R. (PG) Dept. of General Medicine	Prof. Dr. A.K. Badrinath Dept. of General Medicine
11.	Study of correlation of stroke prediction scores in heart failure with reduced ejection fraction patients without atrial fibrillation	Dr. P. Ragavi (PG) Dept. of General Medicine	Prof. Dr. A.K. Badrinath Dept. of General Medicine
12.	A study on serum cytokeratin 18 level in non-obese and non-alcoholic fatty liver disease in a tertiary setup	Dr. Pravin Coumar (PG) Dept. of General Medicine	Dr. G. Premkumar, Dept. of General Medicine
13.	Serum levels of folic acid and homocysteine in psoriasis patients – A case control study	Dr. E. Ragul Raj (PG) Dept. o Dermatology	Dr. K.Karthikeyan Dept. of Dermatology
14.	A study on correlation of serum superoxide dismutase level with severity of alcoholic peripheral neuropathy	Dr. Adrin Suthir (PG) Dept. of General Medicine	Dr.M.K. Uthaya Sankar Dept. of General Medicine Dr. Balachandran M. Dept of Neurology

Completed projects

S. No	Project Title	Principal Investigators	Co- Principal Investigators
1.	gyrA ser83 mutation analysis in Escherchia Coli and Klebsiellapneumoniae in a tertiary care hospital, puducherry.	Dr. G. Muthu Research Scientist CRL	–
2.	Lipid peroxidation and antioxidants with lipid profile in pulmonary tuberculosis.	Miss. K. Elakiya Biochemistry	Dr. S. Sumathi Biochemistry
3.	Causative factors for elevated serum transaminases and their relation with oxidative stress in a tertiary hospital	Miss. J. Yogapriya Biochemistry	Dr. S. Asmathulla Biochemistry
4.	Mineral content in urine of patients with urinary tract infection.	Mr. R. Rajprasath Biochemistry	Dr. S. Asmathulla Biochemistry
5.	Evaluation of oxidative stress, stress induced protein damage and protein bound Sialic acid in diabetic reti4nopathy	Dr. Swithra Biochemistry	Dr. S. Sumathi Biochemistry
6.	Oxidative stress, Lipid levels in fatty liver disease	Ms. Jayashree Student	Ms.G.Agilandeswari Biochemistry
7.	Evaluation of association of serum leptin with chronic complications of diabetes and glycemic control	Dr. Hariharan, PG Student	Dr. S. Sumathi Biochemistry
8.	Anti-Mullerian hormone level in poly cystic ovary syndrome and its correlation with ovarian morphology	Dr. Sivaranjini PG Student	Dr. Sasikala, OB&G
9.	Evaluation of Inflammatory, Oxidative Stress And Serum Testosterone Levels among Male Patients With Chronic Obstructive Pulmonary Disease	Dr. S. Sumathi Biochemistry	Dr. Yuvarajan, MD, pulmonary medicine
10.	Evaluation of oxidative stress and stress induced protein changes in psoriasis	Dr. Ashok Biochemistry	Dr.D. Rajagovindan Biochemistry
11.	Evaluation of Inflammatory, Oxidative Stress And Serum Testosterone Levels among Male Patients With Chronic Obstructive Pulmonary Disease	Dr. Srivatsan (PG) Dept. of Biochemistry	Dr. Sumathi, Dept. of Biochemistry, Dr. Yuvarajan, Dept. of Pulmonary Medicine
12.	Comparative efficacy of pregabline, Gabapentin, lamotrigine in paetalihel induced, peripheral neuropathy in animal model	Dr. Ramesh Kannan, PG, Dept. of Pharmacology	Dr. Mangayarkarasi, Professor, Dept. of Pharmacology
13.	Efficacy of 20% phenol in treatment of alopecia areata	Dr. Tejasri (PG) Dept. of Dermatology	Dr. Rangaraj Dept. of Dermatology
14.	Determination of helicobacter pylori virulence markers in clinical isolates by molecular typing and its association in pathogenesis	Dr. R. Balamurugan, Research Scientist, CRL.	–
15.	Leptin gene polymorphism and pro-inflammatory cytokines profile among Coronary artery disease patients with clustered cardiovascular diseases risk factors	Dr. Ashida T.S Department of Cardiology	Dr. R. Balamurugan, Research Scientist, CRL.
16.	Prevalance and Molecular characterization of Extended Spectrum Beta Lactamase (ESBL) producing bacteria in rural tertiary care hospital, Puducherry.	Dr. Sunil S. Shivekar Dept. of Microbiology	Mr. M. Kaviraj Central Research Lab
17.	Prevalence and Molecular Characterization of HHV 6 and HHV 7 in patients with PityriasisRosea (PR) using polymerase chain reactionin a tertiary care hospital, puducherry.	Dr. M.Rangaraj,MD DVL, Assistant Professor, Department of Dermatology, Venereology &Leprology	Dr. K. Karthikeyan Professor, Department of Dermatology Dr. R.Balamurugan, Research Scientist, CRL
18.	Molecular diagnosis of Prolidase deficiency.	Dr. David Polly Dept. of Dermatology	Dr. K.Karthikeyan, Dept. of Dermatology Dr.S.Asmathulla Dept. of Biochemistry
19.	To study VKORC1 gene polymorphism and CYP2C9 polymorphism status in patients on Acenocoumoral and its effect on therapeutic response.	Dr. S. Meghana (PG) Dept. of General Medicine	Dr. S. Girija, Dept. of General Medicine
20.	Influence of MDR1 polymorphism rs1045642 and rs1128503 on Metformin response in South Indian patients with type 2 diabetes mellitus.	Dr. T. VijayaSanthi (PG) Dept. of Pharmacology	Dr. Nitya Dept. of Pharmacology
21.	Association of genetic polymorphism of TCF7L2 gene among gestational diabetes mellitus subjects of South India	Dr. S. Suganya (PG) Dept. of Biochemistry	Dr. S. Asmathulla Dept. of Biochemistry
22.	The study of prevalence and molecular characterization of Helicobacter pylori in dyspepsia	Dr. S. Yogesh (PG) Dept. of General Medicine	Dr. M.K.Uthaya Shankar, Dept. of General Medicine Dr. Thirumal. P Dept. of Gasteroenterology
23.	Study of Vitamin-D Receptor gene polymorphism and to analyse the allele frequency among Chronic Kidney Disease patients in South Indian population	Dr. B. Ramya, II year Post Graduate, Dept. of Biochemistry	Dr. S. Asmathulla, Professor and Head, Dept. of Biochemistry
24.	Antibiotic resistance pattern of Mycobacterium leprae among the patients of pre and post treatment tenure.	Dr. B. Manjula, II year Post Graduate, Dept. of Dermatology, Venereology &Leprology	Dr. HimaGopinath, Asst. Professor, Dept. of Dermatology, Venereology &Leprology
25.	Evaluation of fine needle aspiration findings in Lymphadenitis – study in a tertiary care hospital.	Dr. Shanmugasundari, I year Post Graduate, Dept. of Pathology	Dr. ErliAmel Ivan, Professor, Dept. of Pathology
26.	Measurement and correlation of HDL subfraction in patients with Coronary Artery Disease and Type-2 Diabetes Mellitus	Dr. BalajiVenkateshwaran. M II year Post Graduate, Dept. of General Medicine	Dr. Badrinath A.K Professor, Dept. of General Medicine
27.	An in vitro study of the antiviral efficacy of Plectranthusamboinicus stem extract against Dengue virus (DENV).	Dr. R. Meenakshi (PG), Dept. of Pharmacology	Dr. Meher Ali Dept. of Pharmacology
28.	Influence of SLC22A1 rs628031 and SLC47A1 rs2289669 genetic polymorphism on metformin response in South Indian patients with type 2 diabetes mellitus	Dr. D. Anuranjani, II year Post Graduate, Dept. of Pharmacology	Dr. S. Asmathulla Dept. of Biochemistry
29.	A study on genetic polymorphism of Interleukin-6and Interleukin-10 and their association with cardiometabolic risk factors in Hashimoto’s Thyroiditis	Mrs. Rajarajeswari. R, Asst. Prof, Dept.of Biochemistry.	–
30.	Effect of Ethanolic extract of Moringaoleifera leaf on testis of Wistar rats exposed to 4G cell phone radiation.	Mrs. R. Sudha, Tutor, Dept. of Anatomy.
31.	Role of Beta-2 Microglobulin in Acute Ischaemic stroke – A prospective study	Dr. D. V. Rangarajan (PG) Dept. of General Medicine	Dr. S. Girija, Dept. of General Medicine
32.	Mid Regional Pro-Adrenomedullin in Heart failure	Dr. M. Raja (PG) Dept. of General Medicine	Dr. S. Girija, Dept. of General Medicine
33.	A study on the role of Neurofilament light chain marker in predicting outcomes in in-patients after stroke	Dr. P. Varsha (PG) Dept. of General Medicine	Dr. K.N. Vishwanathan, Dept. of General Medicine
34.	A study of N-Terminal pro Brain Natriuretic Peptide levels in T2 Diabetes Mellitus patient with normal LV function	Dr. V. Aravindkumar (PG) Dept. of General Medicine	Dr. A.K. Badrinath, Dept. of General Medicine
35.	Correlation of serum Proenkephalin (PENK) levels with renal outcomes in patients with Sepsis admitted in critical care setting	Dr. N. Kaviraj (PG) Dept. of General Medicine	Dr. K.N. Vishwanathan, Dept. of General Medicine

List of Publications

S.No	Article
1.	Manikannan Mathayan, Arumugam Suresh, Rangasamy Balamurugan, Selvaraj Jayaraman. Immune stimulation effects of Pongamia pinnata extracts, an in-vitro analysis. Research J. Pharm. and Tech. 13(1): January 2020.
2.	Dinesh D, Vidjai Vikram, Balasubramanian S, Suneeth P. Lazarus, Suresh Kumar K, Rajprasath R. A Study on the Effect of Lateral and Sitting Positions in Spinal Anesthesia for Cesarean Sections. Indian Journal of Anaesthesia and Analgesia. 2020;7(1Part-I):33–40.
3.	Rangarajan Murgaiyan, Karthikeyan kaliyaperumal, Balamurugan Rangasamy. Prevalence and Molecular characterization of Human Herpes Virus 6 and 7 in patients with Pityriasis Rosea using Polymerase Chain reaction in a tertiary care hospital, Puducherry. Int. J Res Dermatol. 2019 Nov;5(4):728-731.
4.	Murshid A, Suresh Kumar K, Balasubramanian S, Suneeth P. Lazarus, Vidjai Vikram, Rajprasath R. A comparative study on the Endotracheal Tube cuff pressure changes between Supine and Prone in patients undergoing Prone position surgeries. Indian Journal of Anaesthesia and Analgesia.September – October 2019;6(5):1599-603.
5.	Ashida T.S, Balamurugan R. Effect of Intracoronary Nicorandil compared to Nitroglycerin on Coronary Diameter and Hemodynamics following Balloon Dilatation during Elective PTCA. Journal of Cardiovascular Medicine and Surgery. 2019;5(2):57-60.
6.	Mangaiyarkarasi T, Gopal Rangasamy, Sunil S. Shivekar, Kaviraj Mahadevan, Rajprasath Rajaraman, Balamurugan Rangasamy. Epidemiology of Dengue in rural area of Indian union territory. National Journal of Laboratory Medicine. (Submitted: April 2019, Status: Under Review)
7.	Arulmani A, Suresh Kumar K, Balasubramanian S, Suneeth P. Lazarus, Sanmugapiriya K, Rajprasath R. Comparative Study of LMA Supreme versus I-gel in Patients Undergoing Laparoscopic Surgeries with Positive Pressure Ventilation. Indian Journal of Clinical Anaesthesia. March-April 2019;6(2):547-554.
8.	Badrinath, Balasubramanian, Suresh Kumar, Suneeth P. Lazarus, Rajprasath. Table Tilt versus Pelvic Tilt position for preventing Hemodynamic changes during Spinal Anaesthesia for Caesarean Section. Indian Journal of Clinical Anaesthesia. Indian Journal of Clinical Anaesthesia. March-April 2019;6(2):399-406.
9.	Gopal V, Gopal R, Rupavani, Mangaiyarkarasi T. Clinico-etiological study of vaginal discharge in adult women – A hospital based study.Indian J Microbiol Res. 2018;5(4):535-537.
10.	Manikannan Mathaiyan, Arumugam Suresh, Rangasamy Balamurugan. Binding property of HIV p24 and Reverse transcriptase by chalcones from Pongamia pinnata seeds. Bioinformation 2018; 14(6): 279- 284.
11.	Karthikeyan K, Polly D, Asmathulla S, Balamurugan R, Kaviraj M. Topical proline therapy in prolidase deficiency. Clin Exp Dermatol. 2018 Jun 25; DOI: 10.1111/ced.13702.
12.	Srimathy A Jain, Sutapa Das, M. Subashini, Kaviraj Mahadevan. Determination of the Proportion of Refractive Errors in Patients with Primary Complaint of Headache and the Significance of Refractive Error Correction in Symptoms Relief. April-June 2018;4(2):258-262.
13.	Balasubramanian. S, Kartheek Hajeebu SSS, Suresh Kumar. K, Suneeth P. Lazaras. Prospective observational study on the incidence of Postoperative Sore Throat in patients undergoing Endotracheal intubation under General Anaesthesia. Indian Journal of Clinical Anaesthesia. 2018 Sep;5(9):1476-81.
14.	A. Arunkumar, M. Rajan, Ramkumar, Riyaz. Cardiac surgery procedures in a rural tertiary care teaching hospital – our experience. Journal of Cardiovascular Medicine and Surgery. 2018 Sep;4(3):45-48.
15.	Ashida T.S, Sriram R, Balamurugan R. Ambulatory blood pressure profile in hypertensive patients with special reference to early morning blood pressure surge and its relation to hypertensive end organ damage and severity of coronary artery disease. Journal of Cardiovascular Medicine and Surgery. 2018 Sep;4(3):49-54.
16.	S. Chaitra, Sutapa Das, M. Subhashini, M. Kaviraj. A retrospective study of pterygium cases treated in a tertiary care hospital at Puducherry. International Journal of Ocular Oncology and Oculoplasty. Dec 2017;3(4):273-276.
17.	Sutapa Das, Vishwanandha N.R., Sindhu, M. Subhashini, Kaviraj Mahadevan. A study on the angle of anterior chamber in relation to duration of diabetes mellitus and stages of diabetic retinopathy. Indian Journal of Clinical and Experimental Ophthalmology. Sep 2017;3(3): 270-273.
18.	M. Rajan, A. Arunkumar, Harshavardhan K., Nagarajan N. Case Series of Intra Cardiac Myxomas: A Single Institutional Experience. Journal of Cardiovascular Medicine and Surgery. 2017 Jan;3(1):5-11.
19.	Julius A, Vedasendiyar R, Devakannan A, Rajaraman S, Rangasamy B, Saravanan V. Effect of Hesperidin for its Anti-Proliferative Activity on Liver Cancer and Cardio Vascular Diseases. Research Journal of Pharmacy and Technology. 2017 Jan 28;10(1):307–8.
20.	Saleem Mohamedali, Nagma Rafi, Kaviraj Mahadevan, Gopal Rangasamy. Speciation of enterococci isolated from clinical specimens and determination of HLG and vancomycin resistance. J. Evolution Med. Dent. Sci. May. 04, 2017; 6(36): 2973-2976.
21.	Anbarasi AC, Divya N , Subhashini M , Sutapa Das4 , Kaviraj Mahadevan. Analysis of the effects of cataract surgery on corneal sensation variation after SICS and phacoemulsification. Indian Journal of Clinical and Experimental Ophthalmology, December,2016;2(4): 287-289.
22.	NP Vidhya, Sutapa Das, R. Priyadarshini, M. Subashini4, Kaviraj Mahadevan., A comparative study on the intraocular pressure among diabetic and non-diabetic patients. Indian Journal of Clinical and Experimental Ophthalmology, December,2016;2(4): 378-380.
23.	Balamurugan R., SaleemM., Kaviraj M., R., Maraudavanan M., A study on the rate of vacA genotypes of h.pylori in gastric biopsies obtained from patients with symptomatic upper GI disorders. Int.J.Curr.Microbiol.App.Sci.2016.5(12): 603-608.
24.	Balamurugan R., Saleem M., Gopal R., Kaviraj M., Mangaiyarkarasi T., Sunil S. Shivekar., Kalaiselvan G. Prevalence of HIV seropositivity among the patients attending tertiary care hospital at Puducherry, India. Int J Res Med Sci. 2016; 4(7): 2725-7.
25.	R. Balamurugan, Sunil S. Shivekar, R. Gopal, M. Kaviraj, T. Mangaiyarkarasi and M. Saleem Seroprevalence of Dengue in Rural Tertiary Care Hospital at Puducherry-A Retrospective Study. Int.J.Curr.Microbiol.App.Sci. 2016: 5(6): 130-4.
26.	Balamurugan R., Gopal R., Saleem M., Kaviraj M., Sunil S. Shivekar., Mangaiyarkarasi T Prevalence of hepatitis B surface antigen among patients attending a rural teaching hospital at Puducherry. Indian J Microbiol Res 2016:3(1):74-6.
27.	Anand.S Patil., Maraudavanan .R., Rajesh Kumar., Kaviraj M., Balamurugan .R. Histopathological Evaluation of Endoscopic Biopsies in patients with lesional gastrointestinal tract disorders. Journal of evolution of medical and dental sciences. January 2016: 5(1);1-3.
28.	Saleem M., Marudavanan R. , Gopal R. , Sunil S shivekar , Mangaiyarkarasi T. A comparative study of rapid urease test and dilute carbol fuchsin staining technique for diagnosis of Helicobacter pylori infection. Int J Res Med Sci. 2015 Dec;3(12):3608-3610.
29.	E. Ananthamurugan, M. Saleem, R. Gopal, S. Sunil Shivekar, M. Kaviraj, R. Balamurugan. Prevalence of helicobacter pylori infection in patients with atrophic gastritis and role of dark field microscopy in diagnosis. Journal of evolution of medical and dental sciences. November 2015: 4(93);15873-5.
30.	B. Arjun, A. Annamalai, R. Balamurugan, Sunil S. Shivekar, M. Kaviraj. A clinico-endoscopic study of upper GI disorders in rural population of Pondicherry Int J Cur Res Rev. October 2015: 7(20);37-40.
31.	M. Saleem, T. V. Subha, R. Balamurugan, M. Kaviraj, R. Gopal. Bacterial Profile and Antimicrobial Susceptibility Pattern of Surgical Site Infections – A Retrospective Study. Indian Journal of Applied Research. October 2015: 5(10);204-6.
32.	Sunil S Shivekar, R Manikandan, R Balamurugan, M Kaviraj, A Suresh. Incidence of MDR- bacterial colonization in the surgical ward patients in rural tertiary care hospital, Puducherry. International Journal of Recent Trends in Science and Technology. September 2015:16(2);478-81.