PSO1-Understand the biochemical basis of health

PSO2-Understand the biochemical basis of diseases and their complications

PSO3-Understand the molecular aspects of cellular events

PSO4-Understand the genetic basis of diseases and their diagnosis

PSO5-Understand the nutritional importance of in health and diseases

PSO6-Understand the basis and rationale of Biochemical laboratory tests

PSO7-Demonstrate the ability to interpret the laboratory investigation results in clinical context

At the end of the MD training program in Biochemistry, the post graduate student should be able to:

1. Explain clearly concepts and principles of biochemistry and cell biology, including correlations of these with cellular and molecular processes involved in health and disease.
2. Develop skills as a self-directed learner, recognize continuing educational needs; use appropriate learning resources and critically analyze relevant published literature in order to practice evidence-based biochemistry.
3. Demonstrate competence in basic concepts of research methodology and epidemiology.
4. Effectively teach biochemistry to undergraduate students in medicine and allied health science courses to make them competent health care professionals.
5. Set up/supervise /manage a diagnostic laboratory in Biochemistry in a hospital, ensuring quality and reliable diagnostic service.
6. Develop the desired managerial and leadership skills and function as a productive member of a team engaged in health care, research and education.
7. Provide clinicians with consultation services for diagnostic tests in biochemistry and in interpretation of laboratory results.
8. Demonstrate skills in documentation of reports.
9. Conduct Clinical and Molecular research which has an impact on the patient health care and treatment modalities.
10. 10. Carry out a research project from planning to publication and be able to pursue academic interests and continue life-long learning to become more experienced in all the above areas and to eventually be able to guide postgraduates in their thesis work.

PEO1-Acquisition and transfer of knowledge, skills, attitude and professionalism to undergraduate and postgraduate students for quality care and outcome

PEO2-Acquire, conduct, interpret, publish and translate knowledge and skills relevant in improving the contemporary medicine.

PEO3-Coordinate, communicate and collaborate with national and international networks to update and disseminate information related to human well being

Department has library facility with text books and journals of latest editions. The library contains 282 books of 146 titles.

Student practical lab is equipped with five working tables to accommodate 80 students simultaneously. All work stations are supported by reagent racks, water sinks and properly maintained gas burners.

The Clinical Biochemistry Laboratory was established in July, 2004. It is a well equipped, computerized, air conditioned laboratory providing round the clock patient care services.

Our Clinical Biochemistry lab is NABL accredited according to the ISO 15189:2012 Standards.

Clinical Biochemistry lab is connected to HIS software, by which laboratory results are electronically sent to patient care terminus in addition to paper reporting. And once the reports are ready to dispatch, all the patients will receive information about the report dispatch details through SMS to their registered mobile number.

Laboratory Internal Quality (IQ) is maintained with BioRad Quality Control Sample periodically.

Externally laboratory quality is assessed by External Quality Assessment Scheme (EQAS) conducted by CMC, Vellore and BioRad.

1. Fully Automated chemistry Analyzer (Biolis 50i, CPC Diagnostics)
2. Fully Automated chemistry Analyzer (Turbochem Prime, CPC Diagnostics)
3. Fully Automated Chemiluminescence Immuno Assay Analyzer (iFlash 1800, CPC Diagnostics)
4. Fully Automated Chemiluminescence Immuno Assay Analyzer (Centaur XP -Siemens)
5. HbA1c Analyser (Mispa i2, Agappe)
6. HbA1c Analyser (Adams A1c Lite, Arkray)
7. Arterial Blood Gas Analyzer (ABL-80, Radiometer)
8. Arterial Blood Gas Analyzer (ABL-80, Radiometer)
9. Electrolytes Analyser (Rapidchem-744; Siemens)
10. Electrolyte Analyser (Turbolyte, CPC Diagnostics)
11. Semi Automated Analyzer (Microlab-300; Merck)
12. ELISA Reader (Mios mini; Merck)
13. Centrifuge (capacity: 64 buckets) (Neya -Remi)

1. Chromatography chamber (paper & thin layer)
2. Electrophoresis with power pack
3. Spectrophotometer
4. Digital photoColorimeter
5. pH meter
6. Flame photometer with compressor
7. ELISA Reader with washer
8. Centrifuge
9. Electronic weighing balance
10. Triple beam balance
11. Hot air oven
12. Incubator
13. Microscope – Binocular & Monocular
14. Heating mantle
15. Magnetic stirrer
16. Vortex mixer
17. Constant temperature water bath
18. Water bath – single wall type
19. Water bath – double wall type
20. Physical balance
21. Thermometers (0°C -250°C & 0°C -110°C)
22. Electrophoretic chamber with power pack
23. Single istillation plant – steel
24. Micropipettes

Central Research Laboratory (CRL) offered two sections of two weeks training program to MBBS final year students as part of their elective postings from 20-02-2023 to 02-03-2023 and 06-03-2023 to 17-03-2023. The curriculum included theory and practical classes on molecular techniques, biochemical methods, bioinformatics and research methodology.

Central research laboratory conducts research primarily in the area of genomics including genetic polymorphism studies and molecular identification of microbes. The lab hosts HPLC and ELISA facilities for biochemical analysis and enzymatic assays respectively. The equipments are available to PG and MBBS students and faculties for academic projects, short-term research studies, PhD work, institutional and externally funded projects. CRL also has storage facility for blood, plasma, serum, urine and DNA samples.

1. Mathaiyan M, Suresh A, Balamurugan R. Binding property of HIV p24 and Reverse transcriptase by chalcones from Pongamia pinnata seeds. Bioinformation. 2018;14(6):279.
2. Mangaiyarkarasi T, Gopal R, Shivekar SS, Kaviraj M,Rajaraman R, Balamurugan R. Analysis of epidemiological and demographic component of dengue in rural Puducherry – A hospital based study. Indian Journal of Microbiology Research. 2019;6(3):225-228.
3. Mathayan M, Suresh A, Balamurugan R, Jayaraman S. Immune Stimulation effects of Pongamia pinnata extracts, an In vitro Analysis. Research Journal of Pharmacy and Technology. 2020;13(1):308-312.
4. Jain SA, Das S, Subashini M, Mahadevan K. Determination of the proportion of refractive errors in patients with primary complaint of headache and the significance of refractive error correction in symptoms relief. Indian Journal of Clinical and Experimental Ophthalmology. 2018;4(2):258-262.
5. Ahamed AM, Kumar KS, Balasubramanian S, Lazarus SP, Vikram V. A Comparative Study on the Endotracheal Tube Cuff Pressure Changes between Supine and Prone in Patients Undergoing Prone Position Surgeries. Indian Journal of Anaesthesia and Analgesia. 2019;6(5):1599-1603.
6. Dinesh Babu D, Vidjai Vikram S, Bala Subramanian S, Lazarus SP, Suresh Kumar K, Rajprasath R. A Study on the Effect of Lateral and Sitting Positions in Spinal Anesthesia for Cesarean Sections. Indian Journal of Anaesthesia and Analgesia. 2020;7(1) (Part-I):33–40.
7. Ashida TS, Balamurugan R. Effect of Intracoronary Nicorandil compared to Nitroglycerin on Coronary Diameter and Hemodynamics following Balloon Dilatation during Elective PTCA. Journal of Cardiovascular Medicine and Surgery. 2019;5(2):57-60.
8. Karthikeyan K, Polly D, Asmathulla S, Balamurugan R, Kaviraj M. Topical proline therapy in prolidase deficiency. Clinical and Experimental Dermatology. 2019;44(3):344-346.
9. Murugaiyan R, Kaliyaperumal K, Rangasamy B. Prevalence and molecular characterization of human herpes virus 6 and 7 in patients with pityriasis rosea using polymerase chain reaction in a tertiary care hospital, Puducherry. International Journal of Research. 2019;5(4):728-731.

1. Central Research Laboratory in association with the Department of Biochemistry, Sri Manakula Vinayagar Medical College and Hospital organized a one day workshop on ‘DNA isolation and separation’ on 17^th February 2023. The workshop offered training to 25 students from School of Allied Health Sciences on DNA isolation from whole blood sample and further separation by agarose gel electrophoresis.
2. Second phase of the workshop on ‘DNA isolation and separation’ organized by CRL in association with the Department of Biochemistry, Sri Manakula Vinayagar Medical College and Hospital was conducted on 28^th April 2023. The workshop offered training to 17 students from School of Allied Health Sciences.

The Department is involved in teaching programmes for MBBS, B.Sc MLT & DMLT (AHS), Nursing (B.Sc), Post B.Sc Nursing, BPT (Physiotherapy) and M.D (Biochemistry) courses.

Includes lectures, tutorials, small group discussion, integrated class, early clinical exposure, seminars based and AETCOM on the syllabus prescribed by the NMC.

• Competency based Lecture class
• Tutorial class
• Practical class & demonstration
• Integrated class (Horizondal & Vertical integration)
• Early clinical exposure
• Small group discussion: Clinical case-based chart discussion
• AETCOM class
• MCQ (clinical case based) training on LMS portal
• Academic enrichment by conducting Quiz program
• Concept mapping of inborn errors of metabolism

• Competency based Lecture class
• Tutorial class
• Practical class & demonstration
• Integrated class (Horizondal & Vertical integration)
• Early clinical exposure
• Small group discussion: Clinical case-based chart discussion
• AETCOM class
• MCQ (clinical case based) training on LMS portal
• Academic enrichment by conducting Quiz program
• Concept mapping of inborn errors of metabolism

Training of Postgraduates is an important part of departmental activities. The post graduates undergo full time residency program.

The objectives of the training course in MD Biochemistry are:

• Teach requisite knowledge to the under graduate medical students.
• To teach laboratory skills to other medical / paramedical team members.
• To carry out routine investigations, internal quality control measures and data analysis in Clinical Biochemistry Lab
• To do case presentations on regular diseases and work-up of rare laboratory findings
• To inculcate the principles of research methodology, so as to enable the resident to write scientific paper for thesis, publication in reputed journals and presentation in national and international conferences.

Academics are of paramount importance in our postgraduate residency program. Acquisition of practical competencies being the keystone of postgraduate medical education, postgraduate training is skill-oriented. Learning in postgraduate program is essentially self-directed and primarily emanating from clinical and academic work. The formal sessions are merely meant to supplement this core effort.

• Seminar
• Journal Club
• Case discussion
• Theory and practical discussion
• Internal & external quality control – group discussion
• Peripheral posting in clinical departments

Central Research Laboratory is equipped with instruments to carry out research on Genomics and Proteomics.

Clinical Biochemistry Laboratory has facilities to conduct research activities in Endocrinology, Immunology and Clinical chemistry.

Faculties of department of Biochemistry have various projects in Molecular Biology, chronic diseases, autoimmune diseases & Endocrinology.

Publications:

• Asmathulla S, Rajagovindan D, Kasthuri TB, Vani G, Jakanattane V, Sathiyapriya V. Insulin Resistance : Its association with cardiovascular disease risk in pregnancy induced hypertension. Biomedicine 2010;30(4):554-559
• Asmathulla S, Koner BC, papa D. Does oxidative stress play a role in altered serum protein homeostasis in pregnancy – induced hypertension? Acta Physiol Hung 2011;98(3):339-46
• Asmathulla S, Rajagovindan D, Sathyapriya V, Pai B. Prevalence of prehypertension and its relationship to cardiovascular disease risk factors in Puducherry. Indian J Physiol Pharmacol 2011;55(4):343-50
• Sasmita Mishra, P. Padmanaban, G.N. Deepti, G.Sarkar, S. Sumathi, B.D.Toora- Serum Magnesium and Dyslipidemia in Type-2 Diabetes Mellitus, Biomedical Research 2012; 23 (2): 295-300
• Asmathulla S, Ragunathan, Ramchandar and Rajarajeswari R. Assessment of Ischemic Heart Disease and its Risk Factors among Asymptomatic Hospital Visitors. International Journal of Biomedical And Advance Research.2013;4(6):414-19
• Asmathulla S, Rupavani, Kripa, Rajarajeswari Insulin Resistance and its relation to Inflammatory Status and Serum Lipids among Young women with PCOS. IJRCOG. 2013;2(3):325-329
• Ashok V, Sumathi S, Asmathulla S, Divya R, Chandra S. Evaluation of lipid levels and physical fitness in Euthyroid and Hypothyroid states. National Journal of Basic Medical Sciences. 2014;4(2):123-127
• Sakthibalan M, Maruti Sawadkar S, Asmathulla S, Erli Amel Ivan, Muthu G. Study of Cardio protective effect of N-acetylcysteine, Vitamin C and enalapril given in combination to prevent doxorubicin induced cardio Toxicity in wistar rats. Journal of Pharmaceutical and Biomedical Sciences. 2013 November; 36(36): 1902-1908.
• Deepti GN, Lakshmi K, Sumathi S. Study on Microalbuminuria in apparently normal postmenopausal women. Asian Journal of Pharmaceutical and Clinical research. 2014;7:87-89
• Abeetha S, Mitali Srivatsava, Shivali Srivatsava. Progression of acute transverse myelitis to multiple sclerosis: A case report. IJBAMR. 2014;3(3):233-236
• Swithraa C, Sumathi S, Asmathulla S, Annapoorna. Evaluation of oxidative stress and protein bound sialic acid in diabetes with and without retinopathy. International journal of Recent Trends in Science and Technology. November 2014; 13(1): 183- 186.
• Mitali Srivastava, Annapurna Kumar, Sumathi S. Association of Lipid Profile with Severity of Retinopathy in Patients with Type 2 Diabetes Mellitus. Journal of Research in Medical Education and Ethics. November 2015.
• Abeetha S, Shiva YogappaTeli, Mitali Srivastava, Divya R, Ashok V. Can sleep deprivation make us sweeter? International Journal of Healthcare & Biomedical Research. 3 (3), April 2015, 69-76.
• Mitali Srivastava, Abeetha, Shivali Srivastava. Posterior Inferior Cerebellar Artery Syndrome (Wallenberg Syndrome) – a case report. International J. of Healthcare and Biomedical Research, Vol.3(2), January 2015, 76-79.
• Hariharan A, Asmathulla S, Suresh S. Does hypovitaminosis D have a role in lipid profile alteration among non-obese diabetics? International Journal of Recent Trends in Science and Technology. August 2015; 16(1): 45-48
• Srivatsan R,Asmathulla S, Girija S. How Accurate is the Pulse Oximetry Reading in an Intensive Care Setup? Int J Pharm Bio Sci. 2015 Oct;6(4):1069-76
• Srivatsan R, Asmathulla S, Girija S. Hepatic and Renal Biochemical Markers as predictors of mortality among critically ill Systemic Inflammatory Response Syndrome patients. Ind J Clin Biochem (published online in February 2018)
• Vinod Babu S, Santhi Silambanan, Krithika B. Osazones of the Uncommonly Encountered Reducing Sugars. International Journal of Interdisciplinary and Multidisciplinary Studies (IJIMS). 2015;2(9):24-29.
• Karthikeyan, D.Polly, S.Asmathulla, R. Balamurugan, M. Kaviraj. Topical proline therapy in prolidase deficiency. Clinical and Experimental Dermatology. (Accepted for publication 17 February 2018)

Department of Biochemistry 2022

Department of Biochemistry 2022

“MED-BIOQUEST” is an inter-college Biochemistry quiz competition conducted by Association of Medical Biochemists of India (AMBI)-Puducherry chapter for the I MBBS students of Puducherry state.

Our students have participated in the quiz program every year and the prizes won by the students each year is as follows:

• S.Asmathulla, received the First Prize for his Best Poster Presentation on “Oxidative stress alters the plasma albumin homeostasis in pregnancy induced hypertension”, during the 33rd Annual Conference of the Clinical Biochemists of India held at AFMC, Pune, during 23rd to 26th of November 2006.
• S.Asmathulla received the Second Prize in the National Biochemistry Quiz conducted during the 33rd Annual Conference of the Clinical Biochemists of India (ACBI) held at AFMC, Pune, during 23rd to 26th of November 2006.
• R.Rajarajeswari, received First prize in Paper presentation for her paper on “Insulin resistance and inflammatory status related to thyroid hormones in hypothyroidism” during the 3^rd National conference, SOBSICON, held at Karpaga Vinayagar Institute of Medical Sciences, Madhuranthagam, Kanchipuram, during 4^th to 6^th of January 2013.
• Balakrishna Pai R received the Best Oral presentation “P S Murthy award” on his paper titled “A study of SNPs of RAGE & its association with micro & macro vascular complications of T2DM in south Indian population during ACBI conference held at Mangalore from 12^th to 15^th Dec 2016

Our laboratory participates in the “ACBI/CMC External Quality Assurance Scheme” conducted by CMC, Vellore since 2006. Our lab secured 1^st rank in 2007, in the above program.

Summary of the ranks hold by our lab for the past seven years is as follows:

f) University Medals in PG Exams: